Advancement of research on ferroptosis in acute kidney injury
10.3969/j.issn.1674-7445.2020.06.004
- VernacularTitle:急性肾损伤过程中铁死亡的研究进展
- Author:
Yuxi QIAO
1
;
Bo WANG
;
Wujun XUE
;
Chenguang DING
Author Information
1. Department of Renal Transplantation, Nephropathy Hospital, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China
- Publication Type:Research Article
- Keywords:
Ferroptosis;
Acute kidney injury;
Ischemia-reperfusion injury;
Glutathione peroxidase 4;
Reactive oxygen species;
Lipid peroxides;
Necrotizing apoptosis;
Autophagy;
Inflammatory response
- From:
Organ Transplantation
2020;11(6):671-
- CountryChina
- Language:Chinese
-
Abstract:
Acute kidney injury (AKI) is often associated with organ donation and renal transplantation, which leads to an increase of fatality rate, hospitalization time and hospitalization costs. In recent years, studies have shown that ferroptosis is closely related to AKI, but the exact molecular biological mechanism has not been clarified, which need more research. In this article, the role of ferroptosis in AKI was reviewed from the aspects of ferroptosis related biomarkers and biological reactions, in order to find a new possible direction for the prevention and treatmentof AKI.
