Regulatory effect of mTOR pathway-mediated autophagy in liver injury
DOI:10.3969/j.issn.1001-5256.2020.11.051
- VernacularTitle:mTOR相关信号通路介导的自噬对肝损伤的调控作用
- Author:
Qian HUANG
1
;
Jingtao LI
;
Yonggang LIU
;
Hailiang WEI
;
Shuguang YAN
;
Yingjun GUO
;
Zhanjie CHANG
Author Information
1. The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712406, China
- Publication Type:Research Article
- Keywords:
autophagy;
liver injury;
mammalian target of rapamycin;
signal transduction
- From:
Journal of Clinical Hepatology
2020;36(11):2621-2625
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy can regulate liver physiology and balance liver metabolism. Autophagy activation has a double-sided and complex effect on liver injury, and it is regulated by many factors and is associated with many protein pathways. This article summarizes the role of mTOR in the regulation of autophagy, which can inhibit or enhance autophagy through the PI3K/Akt upstream signaling pathway and participate in the physiological and pathological changes of related liver diseases. Therefore, this article reviews the research advances in the mTOR/PI3K/Akt autophagy pathway in liver injury, in order to provide new therapeutic targets for related liver diseases.
