Reappraisal of Systematic Reviews of Glucagon-like Peptide- 1 Receptor Agonist in the Treatment of Type 2 Diabetes Mellitus Based on GRADE System
- VernacularTitle:基于GRADE系统的胰高血糖素样肽1受体激动剂治疗2型糖尿病的系统评价的再评价
- Author:
Guan LIAN
1
;
Zhuolin XIE
2
;
Meixuan LI
3
;
Yongkun LI
4
;
Dinghua ZHANG
1
Author Information
1. Dept. of Endocrinology，Gansu Provincial Hospital of TCM，Lanzhou 730050，China
2. Dept. of Diabetes，Gansu Provincial Hospital of TCM，Lanzhou 730050，China
3. Evidence-based Medical Center，Lanzhou University，Lanzhou 730050，China
4. Dept. of Hepatobi liary Surgery，West China Hospital of Sichuan University，Chengdu 610041，China
- Publication Type:Journal Article
- Keywords:
Glucagon like peptide 1 receptor agonist;
Type 2 diabetes mellitus;
Reappraisal of systematic review;
GRADE
- From:
China Pharmacy
2020;31(21):2656-2664
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To reappraise systematic review/Meta-analysis （SRs/MAs）of the efficacy and safety of glucagon-like peptide 1（GLP-1）receptor agonist in the treatment of type 2 diabetes mellitus （T2DM），and to provide evidence-based reference for clinical use of these drugs in the treatment of T 2DM. METHODS ：Retireved from Cochrane library ，PubMed，Embase，CBM， Wanfang database and CNKI ，systematic review/Me ta-analysis about GLP- 1 receptor agonist in the treatment of T 2DM were collected during the inception to Dec. 2019. After data extraction of literatures met inclusion and exclusion criteria ，GRADE system was used to evaluate the quality of evidence included in the study ，and the evidence of efficacy and safety outcome indexes were summarized. RESULTS ：Finally 31 literatures were included ，involving 91 outcome indexes ，and GRADE evidence quality was medium，among which 4（4.4％）were very-low-quality ，33（36.3％）were low-quality ，45（49.5％）were medium-quality ，and 9 （9.9％）were high-quality outcome indicators. The results of evidence summary showed that GLP- 1 receptor agonists were better than or similar to placebo and other oral hypoglycemic drugs ， better than dipeptidyl peptidase 4 （DPP-4） inhibitors in . reducing the level of HbA 1c；better than or similar to placebo ， JDZX2015240） better than other oral hypoglycemic agents and DPP- 4 2276299207@qq.com inhibitors in reducing the level of fasting glucose ；similar to DDP-4 inhibitors，higher than or similar to placebo ，lower than other oral hypoglycemic dru gs in the incidence of hypoglycemia；higher than other oral hypoglycemic drugs ，placebo and DPP- 4 inhibitors in the incidence of diarrhea and nausea ； higher than other oral hypoglycemic drugs and placebo in the incidence of vomiting. CONCLUSIONS ：The evidence quality of systematic review/Meta-analysis about GLP- 1 receptor agonist in the treatment of T 2DM are moderate. These drugs have good clinical efficacy in the treatment of T 2DM，but their safety are not as good as placebo or other oral hypoglycemic drugs.
