Pharmacological mechanism of Qingfei Dayuan Granules for the treatment of pneumonia by network pharmacology
10.11665/j.issn.1000-5048.20200508
- VernacularTitle:基于网络药理学探究清肺达原颗粒治疗肺炎的药理作用机制
- Author:
Dali GAN
1
;
Junfeng SHI
;
Suqin YANG
;
Meixian XIANG
Author Information
1. 中南民族大学药学院
- Publication Type:Journal Article
- Keywords:
Qinfei Dayuan Granules;
network pharmacology;
pneumonia;
mechanism
- From:
Journal of China Pharmaceutical University
2020;51(5):568-576
- CountryChina
- Language:Chinese
-
Abstract:
To explore the potential mechanism of Qinfei Dayuan Granules for the treatment of pneumonia by the network pharmacology, the potential active ingredients and drug targets of Qinfei Dayuan Granules were obtained through the Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine (TCMIP). The "component-target-disease" network and PPI network were constructed by Cytoscape 3.7.2 software, and GO functional enrichment analysis and KEGG pathway enrichment analysis were performed on the TCMIP platform to obtain a multi-dimensional network analysis of the "Chinese medicinal materials-chemical components-key targets-action pathways" and to explore the mechanism of its multi-component multi-target multi-action pathways of Qinfei Dayuan Granules for the treatment of pneumonia. A total of 474 active ingredients and 865 drug targets were identified from Qinfei Dayuan Granules; the key core targets of drugs include NF-κB, TNF-α, MAPK3, IL-1β, PTGS and CASP3, etc.. The results of GO functional enrichment analysis showed that drugs may interfere with inflammation through biological pathways such as immune regulation and apoptosis. KEGG signal pathway enrichment analysis showed that it was mainly related to the diabetic complications AGE-RAGE signaling pathway, IL-17 signaling pathway, T cell receptor signaling pathway and tumor necrosis factor signaling pathway, etc.. Qinfei Dayuan Granules can exert its effect on the treatment of pneumonia through inflammatory response and immune system with multi-ingredient, multi-target and multi-pathway pharmacological characteristics.
