A method for the synthesis of chalcones
10.11665/j.issn.1000-5048.20200501
- VernacularTitle:一种查耳酮类化合物的合成方法
- Author:
Weixian LUO
1
;
Lishou YANG
;
Xiaosheng YANG
Author Information
1. 贵州大学药学院
- Publication Type:Journal Article
- Keywords:
chalcones;
condensation;
polyphosphoric acid/H2SO4;
acetophenones;
benzaldehydes;
synthesis
- From:
Journal of China Pharmaceutical University
2020;51(5):509-513
- CountryChina
- Language:Chinese
-
Abstract:
In this paper,a new method for catalytic synthesis of chalcones from substituted acetophenone and substituted benzaldehyde in polyphosphoric acid/concentrated sulfuric acid system was proposed,and the reaction conditions were optimized. The results showed that the optimized reaction conditions were determined as polyphosphoric acid of 5 equiv. and concentrated sulfuric acid of 20 equiv.,with 1,4-dioxane as solvent at 90 °C for 2 h under nitrogen protection. Twelve chalcones were synthesized with good yield. All target compounds were characterized by IR,HRMS,1H NMR and 13C NMR.
