WNKs: protein kinases with a unique kinase domain.
- Author:
Chou Long HUANG
1
;
Seung Kuy CHA
;
Hao Ran WANG
;
Jian XIE
;
Melanie H COBB
Author Information
1. Department of Medicine, University of Texas Southwestern Medical Center Dallas, Texas 75390, USA. chou-long.huang@utsouthwestern.edu
- Publication Type:Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
- Keywords:
genome, human;
hyperkalemia;
hypertension;
neoplasms;
protein kinases;
pseudohypoaldosteronisms;
WNK1 protein, human
- MeSH:
Amino Acid Sequence;
Animals;
Cell Proliferation;
Cell Survival;
Humans;
Hyperkalemia/enzymology/etiology/genetics;
Hypertension/enzymology/etiology/genetics;
Kidney/enzymology;
Models, Molecular;
Molecular Sequence Data;
Mutation;
Neoplasms/enzymology/etiology/genetics;
Protein Structure, Tertiary;
Protein-Serine-Threonine Kinases/*chemistry/genetics/*metabolism;
Pseudohypoaldosteronism/enzymology/etiology/genetics;
Sequence Homology, Amino Acid;
Signal Transduction;
Syndrome
- From:Experimental & Molecular Medicine
2007;39(5):565-573
- CountryRepublic of Korea
- Language:English
-
Abstract:
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in regulating ion transport were first revealed by the findings that mutations of two members cause a genetic hypertension and hyperkalemia syndrome. More recent studies suggest that WNKs are pleiotropic protein kinases with important roles in many cell processes in addition to ion transport. Here, we review roles of WNK kinases in the regulation of ion balance, cell signaling, survival, and proliferation, and embryonic organ development.
