Human Immunodeficiency Virus-infected men who have sex with men with syphilis: A 5-year multicentre study in Malaysia

Siaw Yen Ong; Min Moon Tang; Izzaty Dalawi; Wooi Chiang Tan; Chin Aun Yeoh; Wee Meng Kho; Pubalan Muniandy; Pui Li Wong; Rukumani Devi Velayuthan; Zhenli Kwan; Chin Chwen Ch&rsquo; ng; Norli Marwyne Mohd Noor; Vijayaletchumi Krishnasamy; Asmah Johar

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Human Immunodeficiency Virus-infected men who have sex with men with syphilis: A 5-year multicentre study in Malaysia

Author: Siaw Yen Ong ¹ ; Min Moon Tang ¹ ; Izzaty Dalawi ² ; Wooi Chiang Tan ³ ; Chin Aun Yeoh ³ ; Wee Meng Kho ⁴ ; Pubalan Muniandy ⁴ ; Pui Li Wong ⁵ ; Rukumani Devi Velayuthan ⁶ ; Zhenli Kwan ⁷ ; Chin Chwen Ch’ng ⁷ ; Norli Marwyne Mohd Noor ⁸ ; Vijayaletchumi Krishnasamy ¹ ; Asmah Johar ¹
Author Information

1. Department of Dermatology, Hospital Kuala Lumpur
2. Clinical Research Centre, Hospital Kuala Lumpur
3. Department of Dermatology, Hospital Sultanah Bahiyah
4. Department of Dermatology, Hospital Umum Sarawak
5. nfectious Disease Unit, University Malaya Medical Centre
6. Department of Medical Microbiology, University Malaya Medical Centre
7. Division of Dermatology, Department of Medicine, Faculty of Medicine, University of Malaya
8. Department of Dermatology, Hospital Sungai Buloh
Publication Type:Journal Article
Keywords: Sexually transmitted infections; syphilis; men having sex with men (MSM); human immunodeficiency virus (HIV)
From: The Medical Journal of Malaysia 2020;75(4):349-355
CountryMalaysia
Language:English
Abstract: Objectives: High rates of syphilis have been reported worldwide among men who have sex with men (MSM). This study aims to describe the clinical pattern and treatment response of syphilis among human immunodeficiency virus (HIV)-infected MSM in Malaysia. Methods: This is a retrospective study on all HIV-infected MSM with syphilis between 2011 and 2015. Data was collected from case notes in five centres namely Hospital Kuala Lumpur, Hospital Sultanah Bahiyah, Hospital Umum Sarawak, University of Malaya Medical Centre and Hospital Sungai Buloh. Results: A total of 294 HIV seropositive MSM with the median age of 29 years (range 16-66) were confirmed to have syphilis. Nearly half (47.6%) were in the age group of 20-29 years. About a quarter (24.1%) was previously infected with syphilis. Eighty-three patients (28.2%) had other concomitant sexually transmitted infection with genital warts being the most frequently reported (17%). The number of patients with early and late syphilis in our cohort were almost equal. The median pre-treatment non-treponemal antibody titre (VDRL or RPR) for early syphilis (1:64) was significantly higher than for late syphilis (1:8) (p<0.0001). The median CD4 count and the number of patients with CD4 <200/μl in early syphilis were comparable to late syphilis. Nearly four-fifth (78.9%) received benzathine-penicillin only, 5.8% doxycycline, 1.4% Cpenicillin, 1% procaine penicillin, and 12.4% a combination of the above medications. About 44% received treatment and were lost to follow-up. Among those who completed 1 -year follow-up after treatment, 72.3% responded to treatment (serological non-reactive – 18.2%, four-fold drop in titre – 10.9%; serofast – 43.6%), 8.5% failed treatment and 17% had re-infection. Excluding those who were re-infected, lost to follow-up and died, the rates of treatment failure were 12.1% and 8.8% for early and late syphilis respectively (p=0.582) Conclusion: The most common stage of syphilis among MSM with HIV was latent syphilis. Overall, about 8.5% failed treatment at 1-year follow-up.