Mechanism of action and clinical application of 17β-hydroxysteroid dehydrogenase 13 in alcohol-related liver diseases
DOI:10.3969/j.issn.1001-5256.2020.10.044
- VernacularTitle:17β-羟基类固醇脱氢酶13在酒精性肝病中的作用机制及临床应用
- Author:
Li LI
1
;
Haizhen CHEN
;
Jing HUANG
Author Information
1. Department of Clinical Laboratory, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
liver diseases, alcoholic;
17-hydroxysteroid dehydrogenases;
gene expression regulation
- From:
Journal of Clinical Hepatology
2020;36(10):2360-2363
- CountryChina
- Language:Chinese
-
Abstract:
As a new hepatocyte-specific lipid droplet-related protein, 17β-hydroxysteroid dehydrogenase 13 (HSD17B13) is involved in hepatocyte lipid synthesis. Recent studies have shown that an insertion-deletion variant of the HSD17B13 gene is associated with a reduced risk of chronic liver diseases; however, the specific biological function of HSD17B13 and its involvement in the pathogenesis of liver diseases remain unclear. This article elaborates on the biological function of HSD17B13, its mechanism of action in alcohol-related liver, and the research advances in clinical application.
