Mechanism of mitochondrial dysfunction in the development of nonalcoholic fatty liver disease
DOI:10.3969/j.issn.1001-5256.2020.10.042
- VernacularTitle:线粒体功能异常在非酒精性脂肪性肝病发生中的机制
- Author:
Zixin XU
1
;
Shengzheng LUO
;
Mingyi XU
Author Information
1. Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine， Shanghai 200080, China
- Publication Type:Research Article
- Keywords:
nonalcoholic fatty liver disease;
mitochondria;
molecular targeted therapy
- From:
Journal of Clinical Hepatology
2020;36(10):2353-2355
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease (NAFLD) includes a series of diseases affected by various complex factors. Mitochondrial dysfunction often occurs in NAFLD and may lead to the progression of hepatitis and liver fibrosis. This article reviews the important role of mitochondrial oxidative stress, respiration, energy metabolism, quality control, and mitochondrial DNA in NAFLD and summarizes the current status of mitochondria-targeted therapy for NAFLD, hoping to provide a new direction for the research and clinical treatment of NAFLD.
