Role of liver X receptor in nonalcoholic fatty liver disease
DOI:10.3969/j.issn.1001-5256.2020.10.041
- VernacularTitle:肝X受体在非酒精性脂肪性肝病中的作用
- Author:
Wenmi LI
1
;
Nan WANG
;
Qian BIAN
;
Qian HUANG
;
Jingtao LI
;
Hailiang WEI
;
Shuguang YAN
Author Information
1. The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China
- Publication Type:Research Article
- Keywords:
non-alcoholic fatty liver disease;
liver X receptors;
cholesterol
- From:
Journal of Clinical Hepatology
2020;36(10):2349-2352
- CountryChina
- Language:Chinese
-
Abstract:
Excessive lipid deposition, liver injury, and insulin resistance are hallmarks in the development and progression of nonalcoholic fatty liver disease (NAFLD). Liver X receptor (LXR) is a transcriptional regulator, and its two cell subtypes, LXRα and LXRβ, play a key role in regulating cholesterol metabolism, inducing anti-inflammation, and reducing insulin resistance. This article reviews the structure and function of LXR and its association with the pathogenesis of NAFLD, in order to provide new ideas and methods for the prevention and treatment of NAFLD.
