Role of exosomes in hepatocellular carcinoma
DOI:10.3969/j.issn.1001-5256.2020.10.038
- VernacularTitle:外泌体在肝细胞癌中的作用
- Author:
Yunting YAO
1
;
Yuanzhong ZHOU
;
Jun LIU
Author Information
1. School of Public Health, Zunyi Medical University, Zunyi, Guizhou 550004, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
exosomes;
neoplasm metastasis
- From:
Journal of Clinical Hepatology
2020;36(10):2333-2339
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are vesicles with a diameter of about 50-150 nm released by a variety of cells and contain miRNA, mRNA, and protein, with the potential to regulate the signal transduction pathways in receptor cells. Exosomes provide nucleic acids and proteins to coordinate cell-cell communication and microenvironment regulation. This article summarizes the latest research advances in the role of exosomes in hepatocellular carcinoma (HCC) and analyzes the effect of exosomes on the development and progression of HCC, including chemotherapy resistance, epithelial-mesenchymal transition, angiogenesis, metastasis, and immune response. The analysis shows that exosomes have a promising future in the treatment of HCC.
