Clinical features of liver function and coagulation function in patients with Alongshan virus infection
DOI:10.3969/j.issn.1001-5256.2020.10.019
- VernacularTitle:阿龙山病毒感染者肝功能和凝血功能临床特点分析
- Author:
Li ZHANG
1
;
Xiaolong LYU
;
Hongqin XU
;
Zedong WANG
;
Wei WANG
;
Bo WANG
;
Wei WEI
;
Junqi NIU
;
Shuzhen HAN
;
Quan LIU
Author Information
1. Department of Emerging Infectious Diseases, The First Hospital of Jilin University, Changchun 130021, China
- Publication Type:Research Article
- Keywords:
Alongshan virus;
liver diseases;
blood coagulation factors
- From:
Journal of Clinical Hepatology
2020;36(10):2258-2260
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical features of liver function and coagulation function in patients with Alongshan virus (ALSV) infection. MethodsClinical data were collected from 27 patients with ALSV infection who were admitted to Inner Mongolia General Forestry Hospital from May 2018 to September 2019, among whom there were 18 male patients and 9 female patients. Related data were extracted, and a database of relevant case reports was established. The descriptive epidemiological method was used to analyze the clinical features of liver function and coagulation markers, and the features of liver injury caused by ALSV infection were analyzed. ResultsFor the 27 patients, the abnormal rates of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), cholinesterase, and total bile acid were 25.9%, 33.3%, 25.9%, 40.7%, 8%, and 8%, respectively; among the 27 patients, 4 (14.8%) had an ALT level of ＞2×upper limit of normal (ULN), 3 (11.1%) had an AST level of ＞2×ULN, 1 (3.7%) had an ALP level of ＞2×ULN, and 5 (18.5%) had a GGT level of ＞2×ULN. Among the 27 patients, 25 (17 male patients and 8 female patients) had the results of bilirubin test, among whom 1 had a reduction in total bilirubin (TBil) (3.30 μmol/L) and 3 had an increase in TBil (23.7 μmol/L, 26.2 μmol/L, and 32 μmol/L, respectively). The abnormal rates of the coagulation markers international normalized ratio, activated partial thromboplastin time, and fibrinogen were 3.7%, 11.1%, and 22.2%, respectively. ConclusionThere is a certain degree of liver injury in patients with ALSV infection, generally with mild symptoms.
