Inhibitory and Eliminating Effects of Yeast-extracted Melanoston on Pigmentation and Preexisting Pigmentation, Respectively.
- Author:
Jeong Soo KIM
1
;
Kyoung Tae PARK
;
Young Seob AHN
;
Hee Joon YU
Author Information
1. Department of Dermatology, College of Medicine, Hanyang University, Seoul, Korea. tuentuen@hanyang.ac.kr
- Publication Type:Clinical Trial ; Original Article
- Keywords:
Melanogenesis inhibitor;
Melanoston
- MeSH:
Animals;
Arbutin;
Epidermis;
Female;
Forearm;
Guinea;
Guinea Pigs;
Humans;
Melanins;
Melanocytes;
Monophenol Monooxygenase;
Pigmentation*;
Skin;
Volunteers;
Yeasts
- From:Korean Journal of Dermatology
2006;44(4):391-398
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Melanoston is a new melanogenesis inhibitor isolated from yeast. However, little is known about the mechanism of this agent in melanogenesis and also its clinical effectiveness on hyperpigmented lesions. OBJECTIVE: The purpose of this study was to examine the inhibitory effect of melanoston on in vivo activity of tyrosinase. METHODS: We assessed tyrosinase activity, which participates in the synthesis of melanin pigment and resides in melanocytes of guinea pig's epidermis, using immunohistochemical methods after application of 0.1% and 0.01% melanoston on the skin of guinea pigs. We also conducted an 8-week clinical trial on 30 women volunteers to determine the clinical efficacy and safety of melanoston. Participants were instructed to apply melanoston and vehicle on 7 small areas of skin on both forearms for 8 weeks, before and after UVB exposure, and they were examined daily for the first week, then weekly thereafter. RESULTS: The lowest level of tyrosinase activity was observed at the 3rd week after application of 0.1% and 0.01% melanoston on the skin of guinea pigs, and melanoston had a relatively strong inhibitory effect on tyrosinase, as compared with vehicle and arbutin. Differences in the degree of pigmentation between areas treated with 0.5% melanoston and application of vehicle only, and between before and after UVB exposure were considered to be significant (p<0.001, on each time). CONCLUSION: We conclude that melanoston has an inhibitory effect on melanogenesis and some eliminating effect on preexisting pigmentation.
