Research advances in systemic therapy for hepatocellular carcinoma in the era of precision medicine
DOI:10.3969/j.issn.1001-5256.2020.10.003
- VernacularTitle:精准医学时代肝细胞癌的系统治疗
- Author:
Guiqi ZHU
1
;
Zheng TANG
;
Yinghong SHI
;
Jia FAN
Author Information
1. Department of Liver Surgery & Transplantation, Zhongshan Hospital, Fudan University, Shanghai 200030, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
precision medicine;
molecular targeted therapy;
immunotherapy
- From:
Journal of Clinical Hepatology
2020;36(10):2173-2178
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in clinical practice and has the features of high incidence rate, poor prognosis, and high mortality rate, and its incidence rate and mortality rate rank among the top malignant tumors in the world. High heterogeneity of HCC affects the evolution and therapeutic response of HCC. Since most HCC patients are in the advanced stage at the time of diagnosis, systemic treatment has become the main treatment option. In recent years, remarkable achievements have been made in molecular targeted therapy and immunotherapy for HCC, and the latest NCCN guidelines for the systemic treatment of HCC show that sorafenib, lenvatinib, and atezolizumab combined with bevacizumab are recommended as the first-line treatment of HCC, and regorafenib, cabozantinib, nivolumab, pembrolizumab, and ramucirumab are the second-line treatment options for HCC. In the era of precision medicine, how to select the optimal individualized systemic treatment regimen is the key problem in the systemic treatment of HCC. This article reviews the advances in the systemic treatment of HCC in the era of precision medicine and discusses the development direction of HCC treatment in the future.
