Pathogenesis of hepatitis B virus-related hepatocellular carcinoma
DOI:10.3969/j.issn.1001-5256.2020.10.002
- VernacularTitle:HBV相关肝细胞癌的发生机制
- Author:
Yongcong YAN
1
;
Kai WEN
;
Kai MAO
;
Zhiyu XIAO
;
Jie WANG
Author Information
1. Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
- Publication Type:Research Article
- Keywords:
carcinoma, hepatocellular;
hepatitis B virus;
carcinogenesis
- From:
Journal of Clinical Hepatology
2020;36(10):2167-2172
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death, and chronic hepatitis B virus (HBV) infection is an important risk factor for HCC. This article introduces the detailed mechanisms of HBV-related HCC, including HBV X protein, immune imbalance, and integration of HBV DNA into the host genome, with a focus on the pathological role and related mechanisms of HBV X protein in HCC. HBV X protein enhances carcinogenesis by promoting tumor cell proliferation, invasion, and metastasis, affecting angiogenesis, promoting cell apoptosis, and interfering with cell metabolism. In-depth studies on the biological functions of HBV X protein, immune imbalance, and HBV DNA integration will help to clarify the pathogenesis of liver cancer and promote the development of novel therapeutic targets for HBV-related HCC.
