Advances in effectively screening anti-tumor peptides
10.16438/j.0513-4870.2020-0513
- VernacularTitle:抗肿瘤多肽的高效筛选方法及研究现状
- Author:
Li-li SHEN
1
;
Jiao-jiao WANG
1
;
Wu-yue CHEN
1
;
Jing ZHOU
1
;
Hong-yue MA
1
;
Hui-qin XU
1
;
Hai-bo CHENG
2
;
Yin LU
3
;
Jin-ao DUAN
1
Author Information
1. Jiangsu Provincial Key Laboratory of High-Tech Research for Formulations / Jiangsu Provincial Collaborative Innovation Center of Chinese Medicine Resources Industrialization Process, School of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing 210023, China
2. Jiangsu Collaborative Innovation Center for Traditional Chinese Medicine Prevention and Treatment of Cancer, Nanjing 210023, China
3. Jiangsu Provincial Key Laboratory of Efficacy and Safety of Traditional Chinese Medicine, Nanjing 210023, China
- Publication Type:Research Article
- Keywords:
anti-tumor peptide;
chromatographic separation;
peptidomics;
phage display technology;
phenotypic screening
- From:
Acta Pharmaceutica Sinica
2020;55(10):2298-2305
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumor is a disease that severely threaten human health. Common chemotherapeutical drugs currently used in clinical practice have some problems in severe side effects and chemoresistance. In contrast, natural venom peptides and artificially designed targeting peptides have excellent biological activities and potential druggability due to their small molecular weights and high affinity to tumor tissues. Thus, the methods for the discovery of anti-tumor peptides have attracted much attention. In this paper, we summarized the types of anti-tumor peptides from recent literatures. Then, we systematically reviewed screening theories, methods and applications based on traditional chromatographic separation, peptidomics, phage display, phenotypic screening, and artificial intelligence. These strategies and technologies will provide a methodological reference for accelerating anti-tumor peptides research.
