The effect of the sesquiterpenes from Flos Farfarae on an OVA-sensitized asthma model in rats
10.16438/j.0513-4870.2020-0492
- VernacularTitle:款冬花总倍半萜对OVA致敏哮喘大鼠干预作用的代谢组学
- Author:
Ya-hui DUAN
1
,
2
;
Xue-mei QIN
1
;
Zhen-yu LI
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China
2. College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China
- Publication Type:Research Article
- Keywords:
asthma;
Flos Farfarae;
sesquiterpene;
mechanism;
metabonomics
- From:
Acta Pharmaceutica Sinica
2020;55(10):2414-2420
- CountryChina
- Language:Chinese
-
Abstract:
Asthma is a chronic inflammatory disease involving eosinophils, mast cells, lymphocytes, neutrophils and other inflammatory cells and immune components. Chinese medicine has unique advantages in the treatment of asthma. In this study an ovalbumin (OVA)-induced asthma model in rats was used to verify the effect of the total sesquiterpenoids of Flos Farfarae (F.F.S) on asthma. The results show that the F.F.S has anti-asthmatic effects. Metabolomic analysis showed that 25 metabolites were changed in asthmatic rats, and 18 of them could be attributed to F.F.S. F.F.S. can block the over-activation of p65 NF-κB, preventing the transmission of pro-inflammatory factor signals to cells. F.F.S. thus could reduce the over-activation of inflammatory cells, inhibiting the secretion of inflammatory factors and further alleviating asthma inflammation. This study lays a foundation for further new drug research. The mechanism of F.F.S. on asthma needs further investigation.
