Research progress in lipid-drug conjugates
10.16438/j.0513-4870.2020-0461
- VernacularTitle:药物-脂质共轭物研究进展
- Author:
Yu-hua MA
1
;
Yu FANG
1
;
Yi BAO
1
;
Peng-cheng LIN
1
;
Guo-qing PAN
1
;
Xiang-yun GAI
1
Author Information
1. Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, Qinghai Engineering Research Center of Modern Tibetan Medicine Development , School of Pharmacy, Qinghai Nationalities University, Xining 810007, China
- Publication Type:Research Article
- Keywords:
lipid-drug conjugate;
fatty acid;
glyceride;
phospholipid;
nanoparticles for drug delivery
- From:
Acta Pharmaceutica Sinica
2020;55(10):2281-2290
- CountryChina
- Language:Chinese
-
Abstract:
The technology of lipid-drug conjugates is developed on the basis of prodrug principle, which overcomes some drawbacks of drugs via increasing the lipophilicity of hydrophilic or poorly soluble drugs to promote the absorption of drugs and enhance the curative effect. This article sums up the research progress of lipid-drug conjugates from the chemical synthesis methods of conjugates, the types of conjugates, the influence on biological activity of drugs, the application in nanoparticles for drug delivery and the mechanism of absorption and degradation.
