Short-term treatment efficacy of NK cells for ovarian cancer ascites
10.3872/j.issn.1007-385x.2020.10.013
- VernacularTitle:NK细胞治疗卵巢癌腹腔积液的近期疗效
- Author:
HU Jianhua
1
;
ZHANG Yan
1
;
JIANG Longwei
1
;
GAO Yanrong
1
;
SHI Ruifang
1
;
ZHAO Hua
1
;
YAO Lu
1
;
JIA Shaochang
1
Author Information
1. Department of Tumor Biotherapy, Qinhuai Medical District of the General Hospital of Eastern Theater Command of PLA, Nanjing 210002, Jiangsu, China
- Publication Type:Journal Article
- Keywords:
ovarian cancer;
ascites;
natural killer cell;
CA-125;
IL-2;
IFN-γ;
TNF-α
- From:
Chinese Journal of Cancer Biotherapy
2020;27(10):1152-1155
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective: To investigate the short-term clinical efficacy and safety of intraperitoneal perfusion of natural killer (NK) cells
in the treatment of ovarian cancer with ascites. Methods: The clinical data of 15 ovarian cancer patients with ascites effusion, who
received NK cell perfusion in the Qinhuai Medical District of the General Hospital of Eastern Theater Command from November 2016
to January 2019, were analyzed. The peripheral blood was collected to isolate the peripheral blood mononuclear cells, and to further
obtain the NK cells after culture. NK cell suspension was intraperitoneally perfused into the abdominal cavity (no less than 2×109 cells/
time). The volume of peritoneal effusion, the level of serum tumor marker CA-125, the level of serum cytokines IL-2, INF-γ and TNF-α
as well as the changes in peripheral blood lymphocyte subsets were detected before and after the treatment; Moreover, the clinical
efficacy and adverse reactions were observed. Results: The effective rate of intraperitoneal perfusion of NK cells was 66.7%, and there
were no obvious treatment-related adverse reactions. Compared with before treatment, the serum tumor marker CA-125 level
significantly decreased after treatment (P<0.05), and the levels of IL-15, IFN-γ and TNF-α increased significantly (P<0.05 or P<0.01),
while there was no significant changes in peripheral blood lymphocyte subsets (all P>0.05). Conclusion: Intraperitoneal infusion of NK
cells in the treatment of ovarian cancer associated peritoneal effusion has a good short-term clinical efficacy with little adverse
reactions, which is a promising method for the treatment of cancerous peritoneal effusion.
- Full text:20201013.pdf
