Expression and clinical significance of miR-191 in cervical cancer tissues
10.3872/j.issn.1007-385x.2020.10.009
- VernacularTitle:miR-191在宫颈癌组织中的表达及其临床意义
- Author:
ZHANG Ying
1
;
MA Ruixia
1
;
DONG Xuecai
1
;
CHEN Caixia
1
Author Information
1. Department of Gynecologic Oncology, Xinxiang Central Hospital, Xinxiang 453000, Henan, China
- Publication Type:Journal Article
- Keywords:
cervical cancer;
miR-191;
pathological indicators;
prognosis;
Cox proportional hazards regression model
- From:
Chinese Journal of Cancer Biotherapy
2020;27(10):1126-1130
- CountryChina
- Language:Chinese
-
Abstract:
[Abstract] Objective: To investigate the expression of miR-191 in cervical cancer tissues and its effect on the patients' prognosis.
Methods: One hundred and seven cervical cancer tissue specimens from patients who underwent surgical treatment and 46 normal
cervical tissue specimens from patients who underwent surgical resection of uterine fibroids (the control group) in Xinxiang Central
Hospital were collected from December 2012 to December 2014. The expression of miR-191 in cancer tissues was detected by qPCR.
All patients were followed up from the first day after surgery, and the follow-up deadline was December 31, 2019. All patients were
followed up for 5 years, with death as the end event. The survival time and 5-year survival rate of the patients were recorded.
Survival analysis was performed using Kaplan-Meier method and the factors affecting survival prognosis were analyzed using Cox
proportional hazard regression model. Results: The expression level of miR-191 in cervical cancer tissues was significantly higher
than that in the tissues from control group (P<0.01). There were significant differences in miR-191 expression among patients with
different high-risk HPV infection status, different pathological grades and FIGO stages, and different lymph node metastasis status
(all P<0.01). The 5-year survival rate of patients in the miR-191 low expression group was significantly higher than those patients in
the high expression group (81.48% vs 33.75%, χ 2
=16.905, P<0.01). Pathological grade, FIGO stage, lymph node metastasis and the
expression of miR-191 were risk factors affecting the prognosis of cervical cancer patients (HR=0.486, 3.065, 2.339 and 2.755, all
P<0.05). Conclusion: miR-191 is highly expressed in cervical cancer tissues, and its expression level increases with the progression of
malignancy. It is expected to become a potential biomarker for early diagnosis and prognosis evaluation of cervical cancer.
- Full text:20201009.pdf
