Research progress of mitochondrial DNA as a pathogenic factor in diseases
- VernacularTitle:线粒体 DNA 致病作用的研究进展
- Author:
Jingxiu FAN
1
;
ZHU Huili
2
Author Information
1. Department of Cardiovascular Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China
2. Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, 610041, P.R.China
- Publication Type:Journal Article
- Keywords:
Mitochondria;
mitochondrial DNA;
pathogenicity;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(10):1242-1246
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial DNA (mtDNA) is the circulating genome in mitochondria, and it is easy to accumulate oxidative damage, causing mitochondrial dysfunction, and then cell dysfunction, and even tissue and body pathological changes, leading to diseases. As a pro-inflammatory, inflammatory, and even predictive factor, mtDNA is directly involved in the inflammatory response and the pathogenesis of many diseases. This article aims to review the current pathogenesis of mtDNA damage and its pathogenic role in various human diseases.
