Association between baseline SUVmax and histological subtypes of ≤2 cm early peripheral lung adenocarcinoma
- VernacularTitle:基线 PET/CT 参数与≤2 cm 临床早期周围型肺腺癌组织学亚型的关系
- Author:
Dong LIN
1
,
2
,
3
;
Shuai WANG
1
,
2
,
3
;
Xiaosang CHEN
1
,
2
,
3
;
Lijie TAN
1
,
2
,
3
Author Information
1. Department of Thoracic Surgery, Zhongshan Hospital,
2. Fudan University,
3. Shanghai, 200032, P.R.China
- Publication Type:Journal Article
- Keywords:
Peripheral type;
lung adenocarcinoma;
PET/CT;
histological subtype
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(10):1182-1186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between the baseline 18F-FDG PET/CT SUVmax and histological subtypes of ≤2 cm early peripheral lung adenocarcinoma (cN0). Methods We retrospectively reviewed the clinical data of consecutive patients who received baseline 18F-FDG PET/CT and underwent anatomic lung resection for ≤2 cm early peripheral lung adenocarcinoma from 2011 to 2014 in our institute. Results A total of 195 patients were enrolled in this study, including 86 males and 109 females, with an average age of 59.96±9.19 years. Twenty-two patients were pathologically confirmed with lymph node metastasis. One hundred and fifty-seven patients were in the subtype group 1, which included lepidic, acinar, and papillary predominant tumors. Thirty-eight patients were in the subtype group 2, which included solid and micropapillary predominant tumors. The 5-year survival rate was 79.0% and 58.0% in the subtype group 1 and subtype group 2, respectively (P=0.006). The median SUVmax was 2.00 (0.30-13.10) and 4.15 (1.20-17.90) in the subtype group 1 and subtype group 2, respectively (P=0.000). Logistic regression suggested that baseline SUVmax≥2.5 was an independent risk factor for the subtype group 2 (OR=6.635, 95%CI 2.510-17.545, P=0.000). The receiver operating characteristic curve suggested that the continuous SUVmax had an moderate predictive value for subtypes (area under the curve was 0.792, 95%CI 0.717-0.866). Conclusion Baseline 18F-FDG PET/CT SUVmax has certain predictive value for histological subtypes of ≤2 cm early peripheral lung adenocarcinoma.
