Progress of hypoxia inducible factor-1 regulating autophagy and apoptosis in cardiomyocytes under hypoxia
- VernacularTitle:缺氧诱导因子-1 调控缺氧状态下心肌细胞自噬和凋亡的研究进展
- Author:
Xiaohong ZHANG
1
,
2
;
Jingpu SHI
3
Author Information
1. 1. Department of Clinical Epidemiology and Evidence-based Medicine, The First Affiliated Hospital of China Medical University, Shenyang, 110032, P.R.China
2. 2. Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110032, P.R.China
3. Department of Clinical Epidemiology and Evidence-based Medicine, The First Affiliated Hospital of China Medical University, Shenyang, 110032, P.R.Chin
- Publication Type:Journal Article
- Keywords:
Hypoxia inducible factor-1;
cardiomyocytes;
autophagy;
apoptosis;
myocardial hypoxia
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(09):1087-1093
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factor-1 (HIF-1) is the main transcription factor and the core regulator for cells to adapt to hypoxia, and oxygen homeostasis is achieved by controlling and utilizing oxygen delivery. Autophagy and apoptosis play an important role in determining cell fate and maintaining cell homeostasis. In recent years, it has been found that the dynamic change of HIF-1 expression plays a key role in the hypoxic adaptive response of cardiomyocytes. The regulation of HIF-1 on autophagy and apoptosis of hypoxic cardiomyocytes determines the survival of cardiomyocytes, which is of great significance for the prognosis of ischemic heart disease.
