Advances in the pathogenesis of aortic dissection
- VernacularTitle:主动脉夹层发病机制研究进展
- Author:
Enzehua XIE
1
;
Juntao QIU
1
;
Jinlin WU
1
;
Cuntao YU
1
Author Information
1. Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, P.R.China
- Publication Type:Journal Article
- Keywords:
Aortic dissection;
pathogenesis;
gene;
non-coding RNA;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2020;27(09):1081-1086
- CountryChina
- Language:Chinese
-
Abstract:
Aortic dissection is a catastrophic emergency with a high mortality rate, and its full pathogenesis remains unknown to researchers, which brings a heavy burden to the individuals, society and family because of its poor prognosis. Improving the efficiency of its diagnosis and treatment and defining the pathogenic mechanism clearly is a research hotspot. Recently, utilizing bioinformatics to find diagnostic biomarker of aortic dissection has attracted the attention of many researchers. Besides, exploring the relationship between pathogenic mechanism and inflammatory process, extracellular matrix degradation, elastic fiber fracture and the phenotypic transformation of vascular smooth muscle cells is also a hot topic. We summarize recent progress made in the pathogenesis of aortic dissection. We hope to identify key molecules driving aortic dissection and provide reliable reference for the diagnosis, medical treatment and prevention of aortic dissection.
