Role of prostaglandin E synthases in liver diseases
DOI:10.3969/j.issn.1001-5256.2020.09.052
- VernacularTitle:前列腺素合酶在肝脏疾病中的作用
- Author:
Jie CAI
1
;
Jihong LU
;
Hang GAO
;
Zhikang WAN
;
Ying SUN
Author Information
1. Department of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221000, China
- Publication Type:Research Article
- Keywords:
liver diseases;
prostaglandins E;
gene expression regulation
- From:
Journal of Clinical Hepatology
2020;36(9):2137-2140
- CountryChina
- Language:Chinese
-
Abstract:
Prostaglandin E2 (PGE2) is a bioactive polyunsaturated fatty acid produced by arachidonic acid, and it is mainly metabolized in the liver and has an important regulatory effect on various liver diseases. Prostaglandin E synthases (PGESs) are important terminal rate-limiting enzymes in the PGE2 synthesis pathway and are involved in the development and progression of liver disease. This article mainly summarizes the role of PGESs in liver injury, hepatitis, and liver cancer in existing studies, hoping to provide a reference for further research on the role of PGESs in liver diseases.
