Research advances in Akkermansia muciniphila and liver injury
DOI:10.3969/j.issn.1001-5256.2020.09.051
- VernacularTitle:嗜黏蛋白阿克曼氏菌与肝损伤关系的研究进展
- Author:
Limin LIU
1
;
Mingjie YAO
;
Duanmin HU
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, China
- Publication Type:Research Article
- Keywords:
Akkermansia muciniphila;
liver injury;
gastrointestinal microbiome
- From:
Journal of Clinical Hepatology
2020;36(9):2133-2136
- CountryChina
- Language:Chinese
-
Abstract:
Liver injury caused by viral and non-viral factors is an important stage of chronic liver disease, and the pathogenesis of liver injury is still a research hotspot. With the deepening of the research on gut microbiota, substantial evidence indicates that gut microbiota participates in the development and progression of liver injury, and it has been confirmed that Akkermansia muciniphila (Akk) has a beneficial effect against liver injury. This article summarizes the role and potential mechanism of Akk in immune-mediated liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. It is believed that Akk may provide new directions and choices for the prevention and treatment of liver injury.
