Research advances in high-risk factors for primary biliary cholangitis
DOI:10.3969/j.issn.1001-5256.2020.09.049
- VernacularTitle:原发性胆汁性胆管炎高危因素的研究进展
- Author:
Hailing LIAO
1
;
Jinhui YANG
Author Information
1. Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650000, China
- Publication Type:Research Article
- Keywords:
cholangitis, sclerosing;
risk factors;
environmental factors;
heredity factors
- From:
Journal of Clinical Hepatology
2020;36(9):2125-2128
- CountryChina
- Language:Chinese
-
Abstract:
Primary biliary cholangitis (PBC) is a multifactorial disease caused by the combined effect of genetic susceptibility and environmental triggers. Among the known risk factors for PBC, environmental factors mainly cause the onset of the disease by disrupting mitochondrial immune tolerance. With the deepening of research, especially the application of genome-wide association study technology, some dangerous genes have been found, such as human leukocyte antigen gene IL and X chromosome monomer. This article reviews the research advances in high-risk factors for PBC.
