Biological characteristics of exosome microRNA and its role in the development and progression of liver fibrosis

VernacularTitle:外泌体microRNA的生物学特征及在肝纤维化发生发展中的作用
Author: Shiwan ZHANG ¹ ; Xueqin YU ; Fang CHEN ; Yihan MEI ; Xiaoping MEI
Author Information

1. Department of Infectious Diseases, Affiliated Hospital of Chuanbei Medical College, Nanchong, Sichuan 637000, China
Publication Type:Research Article
Keywords: liver cirrhosis; exosomes; microRNAs
From: Journal of Clinical Hepatology 2020;36(9):2083-2086
CountryChina
Language:Chinese
Abstract: Exosomes, as a type of multivesicular bodies secreted by various cells in human body, exist in many kinds of body fluids in the body. Exosomes have the structure of lipid bilayer membranes to protect the structure and function stability of their contents and they carry a large number of active substances including microRNA (miRNA) and mRNA. Studies have shown that exosomes and their miRNA are closely associated with the development and progression of liver fibrosis and regulate such process by acting on hepatic stellate cells to change their activation, proliferation, apoptosis, and migration. This article elaborates on the biological characteristics of exosome miRNA and its association with liver fibrosis, analyzes its important role in the development and progression, diagnosis and treatment, and prognostic evaluation of liver fibrosis, and points out that exosome miRNA may become a new potential target for the diagnosis, treatment, and prognostic evaluation of liver fibrosis.