Expression and Significance of PD-1, TIM-3 and VISTA on T Cell of Acute Myeloid Leukemia Patients.
10.19746/j.cnki.issn.1009-2137.2020.03.006
- Author:
Meng-Jun GE
1
;
Kai-Lin XU
1
;
Ting XU
1
;
Ya-Nan TANG
1
;
ZHen-Yu LI
1
;
Zhi-Ling YAN
1
;
Hai-Ying SUN
1
;
Hai CHENG
1
;
Feng ZHU
1
;
Wei SANG
1
;
Yi-Hong HUANG
1
;
Ting-Ting QIU
1
;
De-Peng LI
2
Author Information
1. Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China.
2. Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China,E-mail: Lidepeng30@163.com.
- Publication Type:Journal Article
- MeSH:
B7 Antigens;
CD8-Positive T-Lymphocytes;
Flow Cytometry;
Hepatitis A Virus Cellular Receptor 2;
Humans;
Leukemia, Myeloid, Acute;
Programmed Cell Death 1 Receptor
- From:
Journal of Experimental Hematology
2020;28(3):748-752
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the expression of multiple negative costimulatory molecules on peripheral blood T cells in patients with acute myeloid leukemia (AML) and its affection on prognosis.
METHODS:The peripheral blood samples from patients with newly diagnosed AML, complete remission (CR), and no-remission (NR) were collected, the expression levels PD-1、VISTA and TIM-3 in CD4 and CD8 T cells were detected by flow cytometry , and the clinical data of patients were analyzed.
RESULTS:The expression levels of PD-1、VISTA and TIM-3 of CD4 and CD8 T cells in the newly diagnosed AML patients were significantly higher than those in control group (P＜0.05). The expression levels of PD-1、TIM-3 and VISTA of CD4 and CD8 T cells in the CR group were significantly lower than those in newly diagnosed and the NR group (P＜0.05). The TIM-3 expression level positively correlated with VISTA expression level of CD4 and CD8 T cells in newly diagnosed AML patients (r=0.85 and 0.73). The VISTA and PD-1 expression level of CD4 T cells in newly diagnosed AML, NR after first induction chemotherapy and high risk patients significantly increased (P＜0.05), the TIM-3 expression level of CD8 T cells in high risk group significantly increased (P＜0.05), and the VISTA expression level of CD8 T cells in CBFβ-MYH11 mutation-positive group significantly decreased (P＜0.05).
CONCLUSION:The expression of PD-1、TIM-3 and VISTA in AML peripheral blood T cells may be involved in the immune escape of AML and can be the targets of treatment for acute myeloid leukemia patients.
