Efficacy of Small Dose HAG Regimen Combined with Decitabine in Treatment of Elderly Patients with Acute Myeloid Leukemia.
10.19746/j.cnki.issn.1009-2137.2020.03.018
- Author:
Peng-Ji PAN
1
;
Zhang-Qin LUO
2
Author Information
1. Department of Hematology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China.
2. Department of Hematology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China,E-mail: luozq056@126.com.
- Publication Type:Journal Article
- MeSH:
Aged;
Antineoplastic Combined Chemotherapy Protocols;
therapeutic use;
Cytarabine;
Decitabine;
Disease-Free Survival;
Granulocyte Colony-Stimulating Factor;
Humans;
Leukemia, Myeloid, Acute;
drug therapy;
Survival Rate;
Treatment Outcome
- From:
Journal of Experimental Hematology
2020;28(3):828-832
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the efficacy of small dose HAG combined with decitabine regimen in the treatment of elderly patients with acute myeloid leukemia (AML).
METHODS:134 elderly AML patients treated in our hospital from March 2015 to December 2018 were selected, and the patients were divided into CAG group and combined treatment group. The AML patients in CAG group was treated with CAG regimen, while the AML patients in combined treatment group was treated with small dose HAG regimen combined with decitabine. Efficacy was evaluated after treatment.
RESULTS:After treatment, the OR rate of the patients in combined treatment group was significantly higher than that in CAG group (χ=5.311, P=0.021). The nausea and vomiting rate, infection rate, myelosuppression rate, bleeding rate and intestinal discomfort rate showed no significant difference between the two groups (P＞0.05). The CD3, CD4 and CD8 levels of patients in combined treatment group were significantly lower than those in CAG group (P＜0.05). The result of followed-up for 2 years, showed that the overall survival rate of patients in combined treatment group was significantly higher than that in CAG group [(76.2±6.3)% vs (45.7±7.6)%] (χ=4.214, P＜0.05), while the disease free survival rate of patients in combined treatment group were (57.4±7.7)%, which was significantly higher than that in CAG group (30.3±7.9)% (χ=5.250, P＜0.05).
CONCLUSION:Small dose HAG regimen combined with decitabine for elderly patients with acute myeloid leukemia has a certain curative efficacy.
