Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency.
10.1016/j.gpb.2019.06.003
- Author:
Shahzina KANWAL
1
,
2
,
3
,
4
;
Xiangpeng GUO
1
,
2
,
3
,
4
;
Carl WARD
1
,
2
,
3
,
4
;
Giacomo VOLPE
1
,
2
,
3
,
4
;
Baoming QIN
1
,
2
,
3
,
5
;
Miguel A ESTEBAN
1
,
2
,
3
,
6
,
7
;
Xichen BAO
1
,
2
,
6
,
8
Author Information
1. (1)Joint School of Life Sciences, Guangzhou Medical University and Guangzhou Institutes of Biomedicine and Health, Guangzhou 511436, China
2. (2)Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
3. (3)Laboratory of RNA, Chromatin, and Human Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
4. (4)Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou 510005, China.
5. (5)Laboratory of Metabolism and Cell Fate, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
6. (4)Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMH-GDL), Guangzhou 510005, China
7. (6)Institute for Stem Cells and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: miguel@gibh.ac.cn.
8. (7)Laboratory of RNA Molecular Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China. Electronic address: bao_xichen@gibh.ac.cn.
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Mesenchymal-to-epithelial transition;
Proliferation;
X chromosome reactivation
- From:
Genomics, Proteomics & Bioinformatics
2020;18(1):16-25
- CountryChina
- Language:English
-
Abstract:
The generation of induced pluripotent stem cells through somatic cell reprogramming requires a global reorganization of cellular functions. This reorganization occurs in a multi-phased manner and involves a gradual revision of both the epigenome and transcriptome. Recent studies have shown that the large-scale transcriptional changes observed during reprogramming also apply to long non-coding RNAs (lncRNAs), a type of traditionally neglected RNA species that are increasingly viewed as critical regulators of cellular function. Deeper understanding of lncRNAs in reprogramming may not only help to improve this process but also have implications for studying cell plasticity in other contexts, such as development, aging, and cancer. In this review, we summarize the current progress made in profiling and analyzing the role of lncRNAs in various phases of somatic cell reprogramming, with emphasis on the re-establishment of the pluripotency gene network and X chromosome reactivation.
