Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35-74 Years: Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance.

Qi Qi Wang; Shi Cheng YU; Cheng Dong XU; Jian Jun Liu; Yuan Qiu LI; Man Hui Zhang; Xiao Juan Long; Yun Ning Liu; Yu Fang BI; Wen Hua Zhao; Hong Yan Yao

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Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35-74 Years: Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance.

Author: Qi Qi WANG ¹ ; Shi Cheng YU ¹ ; Cheng Dong XU ² ; Jian Jun LIU ¹ ; Yuan Qiu LI ¹ ; Man Hui ZHANG ³ ; Xiao Juan LONG ¹ ; Yun Ning LIU ⁴ ; Yu Fang BI ⁵ ; Wen Hua ZHAO ⁶ ; Hong Yan YAO ¹
Author Information

1. Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.
3. Peking University Third Hospital, Beijing 100191, China.
4. National Center for Chronic and Non communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
5. Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
6. National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Publication Type:Journal Article
Keywords: Behavioral risk factors; Diabetes; Odds ratio; Selenium; Survey
MeSH: Adult; Aged; China; epidemiology; Diabetes Mellitus; chemically induced; epidemiology; Diet; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Risk Factors; Selenium; deficiency; metabolism; Soil; chemistry
From: Biomedical and Environmental Sciences 2020;33(4):260-268
CountryChina
Language:English
Abstract: Objective:To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35-74 years.
Methods:Data for this study were derived from the China Chronic Diseases and Behavioral Risk Factors Surveillance 2010 survey. Selenium concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in China. A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes, with participants nested within districts/counties.
Results:A total of 69,332 participants aged 35-74 years, from 158 districts/counties were included in the analysis. Concentrations of selenium in soil varied greatly across the 158 districts/counties, with a median concentration of 0.219 mg/kg ( : 0.185-0.248). The results showed that both Quartile 1 (0.119-0.185 mg/kg) and Quartile 4 (0.249-0.344 mg/kg) groups were positively associated with diabetes compared to a soil selenium concentration of 0.186-0.219 mg/kg (Quartile 2), crude odds ratios ( s) (95% ) were 1.227 (1.003-1.502) and 1.280 (1.048-1.563). The values were 0.045 and 0.013, for Quartile 1 and Quartile 4 groups, respectively. After adjusting for all confounding factors of interest, the Quartile 1 group became non-significant, and the Quartile 4 group had an adjusted (95% ) of 1.203 (1.018-1.421) relative to the reference group (Quartile 2), the values was 0.030. No significant results were seen for the Quartile 3 group (0.220-0.248 mg/kg) compared to the reference group.
Conclusion:Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35-74 years.