- Author:
Wei LIU
1
,
2
;
Jia Ke CHAI
1
,
2
;
Bin QIN
3
;
Shao Fang HAN
2
;
Xiao Teng WANG
2
;
Shuai JIANG
2
;
Hai Liang BAI
2
;
Ling Ying LIU
2
;
Yang CHANG
2
;
Xiao Tong YUE
4
;
Yu Shou WU
4
;
Zi Hao ZHANG
2
;
Lang TANG
5
Author Information
- Publication Type:Journal Article
- Keywords: Animal model; Biomechanical effect; Lung injury; Open-field blast; Shock wave
- MeSH: Animals; Biomechanical Phenomena; Blast Injuries; etiology; pathology; Disease Models, Animal; Explosions; Lung Injury; etiology; pathology; Male; Random Allocation; Rats; Rats, Sprague-Dawley
- From: Biomedical and Environmental Sciences 2020;33(5):338-349
- CountryChina
- Language:English
-
Abstract:
Objective:To observe the dynamic impacts of shock waves on the severity of lung injury in rats with different injury distances.
Methods:Simulate open-field shock waves; detect the biomechanical effects of explosion sources at distances of 40, 44, and 48 cm from rats; and examine the changes in the gross anatomy of the lungs, lung wet/dry weight ratio, hemoglobin concentration, blood gas analysis, and pathology.
Results:Biomechanical parameters such as the overpressure peak and impulse were gradually attenuated with an increase in the injury distance. The lung tissue hemorrhage, edema, oxygenation index, and pathology changed more significantly for the 40 cm group than for the 44 and 48 cm groups. The overpressure peak and impulse were significantly higher for the 40 cm group than for the 44 and 48 cm groups ( < 0.05 or < 0.01). The animal mortality was significantly higher for the 40 cm group than for the other two groups (41.2% . 17.8% and 10.0%, < 0.05). The healing time of injured lung tissues for the 40 cm group was longer than those for the 44 and 48 cm groups.
Conclusions:The effects of simulated open-field shock waves on the severity of lung injuries in rats were correlated with the injury distances, the peak overpressure, and the overpressure impulse.