Detection of Pseudorabies Virus Antibodies in Human Encephalitis Cases.

Xiang Dong LI; Shi Hong FU; Ling Yan Chen; Fan LI; Jun Hua Deng; Xuan Cheng LU; Huan Yu Wang; Ke Gong Tian

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Detection of Pseudorabies Virus Antibodies in Human Encephalitis Cases.

Author: Xiang Dong LI ¹ ; Shi Hong FU ^{2
,

3} ; Ling Yan CHEN ¹ ; Fan LI ^{2
,

3} ; Jun Hua DENG ¹ ; Xuan Cheng LU ⁴ ; Huan Yu WANG ^{2
,

3} ; Ke Gong TIAN ¹
Author Information

1. National Research Center for Veterinary Medicine, Luoyang 471003, Henan, China.
2. Department of Viral Encephalitis, NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
3. State Key Laboratory of Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
4. Laboratory Animal Center, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China.
Publication Type:Journal Article
Keywords: Encephalitis; Human infection; Pseudorabies virus
MeSH: Adult; Animals; Antibodies, Viral; blood; China; Encephalitis; immunology; virology; Enzyme-Linked Immunosorbent Assay; Female; Herpesvirus 1, Suid; immunology; Humans; Male; Middle Aged; Prevalence; Pseudorabies; blood; immunology; virology; Retrospective Studies; Seroepidemiologic Studies; Young Adult
From: Biomedical and Environmental Sciences 2020;33(6):444-447
CountryChina
Language:English
Abstract: Pseudorabies virus (PRV), a veterinary pathogen that infects domestic animals as well as wild animals such as wild boar and feral swine, was recently reported to infect human and led to endophthalmitis and encephalitis. A retrospective seroepidemiologic survey was conducted using 1,335 serum samples collected from patients with encephalitis and ELISA positive rates were 12.16%, 14.25%, and 6.52% in 2012, 2013, and 2017, respectively. The virus neutralizing antibody titers of positive samples correlated well with ELISA results. The pseudorabies virus antibody positive rate of patients with encephalitis were higher than that of healthy people in 2017. The above results suggest that some undefined human encephalitis cases may be caused by PRV infection.