Folic Acid Supplementation in Chinese Peri-conceptional Population: Results from the SPCC Study.

Ding Mei Wang; Yi Zhang; Yuan Jiang; Ying YE; Xiang Yuan Huang; Meng Ru LI; Mi JI; Zheng Shan Zhao; Xiao Tian Chen; Wei Sheng; Xiao Jing MA; Stephen Allen; Duo Lao Wang; Wei Li Yan; Guo Ying Huang

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Folic Acid Supplementation in Chinese Peri-conceptional Population: Results from the SPCC Study.

Author: Ding Mei WANG ¹ ; Yi ZHANG ¹ ; Yuan JIANG ¹ ; Ying YE ¹ ; Xiang Yuan HUANG ¹ ; Meng Ru LI ¹ ; Mi JI ¹ ; Zheng Shan ZHAO ¹ ; Xiao Tian CHEN ¹ ; Wei SHENG ^{2
,

3} ; Xiao Jing MA ^{2
,

3} ; Stephen ALLEN ⁴ ; Duo Lao WANG ⁴ ; Wei Li YAN ^{2
,

3} ; Guo Ying HUANG ^{2
,

3}
Author Information

1. Children's Hospital of Fudan University, Shanghai 201102, China.
2. Children's Hospital of Fudan University, Shanghai 201102, China
3. Shanghai Key Laboratory of Birth Defect, Shanghai 201102, China.
4. Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
Collective Name:Shanghai PreConception Cohort Group
Publication Type:Journal Article
Keywords: Birth defects; China; Folic acid supplementation; Peri-conception; Pregnancy
MeSH: Adult; China; Cohort Studies; Cross-Sectional Studies; Diet; Dietary Supplements; analysis; Female; Folic Acid; administration & dosage; Humans; Male; Pregnancy; Surveys and Questionnaires; Vitamin B Complex; administration & dosage; Young Adult
From: Biomedical and Environmental Sciences 2020;33(8):557-565
CountryChina
Language:English
Abstract: Objective:To determine the prevalence and determinants of folic acid (FA) supplementation in Chinese couples planning for pregnancy and in women during early pregnancy.
Methods:This was a cross-sectional study based on the Shanghai PreConception Cohort (SPCC) study. Data on FA supplementation and socio-demographic features were collected using questionnaires. Couples visiting clinics for pre-pregnancy examination and pregnant women at < 14 gestational weeks were recruited in Shanghai, China, between March 2016 and September 2018.
Results:Among the pregnancy planners, 42.4% (4,710/11,099) women and 17.1% (1,377/8,045) men used FA supplements, while 93.4% (14,585/15,615) of the pregnant women used FA supplements. FA supplement use was higher in female pregnancy planners who were older ( : 1.13, 95% : 1.08-1.18), had higher education ( : 1.71, 95% : 1.53-1.92), and were residing in urban districts ( : 1.06, 95% : 1.01-1.11) of FA supplementation; female pregnancy planners with alcohol consumption ( : 0.95, 95% : 0.90-0.99) had lower odds of FA supplementation. In early pregnancy, women with higher educational level ( : 1.04, 95% : 1.03-1.06), who underwent pre-pregnancy examination ( : 1.02, 95% : 1.01-1.03) had higher odds of using an FA supplement; older aged ( : 0.99, 95% : 0.98-0.99), and multigravida ( : 0.97, 95% : 0.96-0.98) had lower odds of FA supplementation.
Conclusion:Although the majority of pregnant women took FA supplements, more than half of the women planning for pregnancy did not. Urgent strategies are needed to improve pre-conception FA supplementation.