Onset of Coronary Heart Disease is Associated with HCMV Infection and Increased CD14 CD16 Monocytes in a Population of Weifang, China.

Hong Zheng LI; Qin Wang; Yi Yuan Zhang; Jin Dong Wang; Hong Juan WU; Mo Gen Zhang; Ji Chen LI; Zhi Jun Liu

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Onset of Coronary Heart Disease is Associated with HCMV Infection and Increased CD14 CD16 Monocytes in a Population of Weifang, China.

Author: Hong Zheng LI ¹ ; Qin WANG ² ; Yi Yuan ZHANG ³ ; Jin Dong WANG ¹ ; Hong Juan WU ⁴ ; Mo Gen ZHANG ³ ; Ji Chen LI ¹ ; Zhi Jun LIU ¹
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1. Department of Medical Microbiology, Weifang Medical University, Weifang 261053, Shandong, China.
2. National Institute for Viral Diseases Control and Prevention, China Center for Disease Control and Prevention, Beijing 102206, China.
3. School of Clinical Medicine, Weifang Medical University, Weifang 261053, Shandong, China.
4. Morphological Laboratory, Weifang Medical University, Weifang 261053, Shandong, China.
Publication Type:Journal Article
Keywords: Antibody; CD14+CD16+ monocytes; Coronary heart disease; Human cytomegalovirus; Weifang
MeSH: Angina Pectoris; epidemiology; virology; China; epidemiology; Coronary Disease; epidemiology; virology; Cytomegalovirus; physiology; Cytomegalovirus Infections; complications; Humans; Incidence; Inflammation; epidemiology; etiology; Leukocyte Count; Monocytes; metabolism; Myocardial Infarction; epidemiology; virology
From: Biomedical and Environmental Sciences 2020;33(8):573-582
CountryChina
Language:English
Abstract: Objective:To investigate the relationship between human cytomegalovirus (HCMV) infection and peripheral blood CD14 CD16 monocytes in the pathogenesis of coronary heart disease (CHD), and to elucidate the mechanism of pathogenesis in CHD by analyzing the correlation between infection, inflammation, and CHD, to provide a basis for the prevention, evaluation, and treatment of the disease.
Methods:In total, 192 patients with CHD were divided into three groups: latent CHD, angina pectoris, and myocardial infarction. HCMV-IgM and -IgG antibodies were assessed using ELISA; CD14 CD16 monocytes were counted using a five-type automated hematology analyzer; mononuclear cells were assessed using fluorescence-activated cell sorting; and an automatic biochemical analyzer was used to measure the levels of triglyceride, cholesterol, high- and low-density lipoprotein cholesterols, lipoprotein, hs-CRp and Hcy.
Results:The positive rates of HCMV-IgM and -IgG were significantly higher in the CHD groups than in the control group. HCMV infection affects lipid metabolism to promote immune and inflammatory responses.
Conclusion:HCMV infection has a specific correlation with the occurrence and development of CHD. The expression of CD14 CD16 mononuclear cells in the CHD group was increased accordingly and correlated with acute HCMV infection. Thus, HCMV antibody as well as peripheral blood CD14 CD16 mononuclear cells can be used to monitor the occurrence and development of CHD.