Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation.
10.1038/s41368-020-00090-5
- Author:
Mohit SHARMA
1
;
Felipe Paiva FONSECA
2
;
Keith D HUNTER
3
;
Raghu RADHAKRISHNAN
4
Author Information
1. Department of Oral Pathology, Sudha Rustagi College of Dental Sciences and Research, Faridabad, Haryana, India.
2. Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
3. Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield, UK.
4. Department of Oral Pathology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India. raghu.ar@manipal.edu.
- Publication Type:Journal Article
- MeSH:
Animals;
Carcinoma, Squamous Cell;
pathology;
Cell Transformation, Neoplastic;
pathology;
Mice;
Mouth Mucosa;
Mouth Neoplasms;
pathology;
Oral Submucous Fibrosis;
pathology;
Stem Cells
- From:
International Journal of Oral Science
2020;12(1):23-23
- CountryChina
- Language:English
-
Abstract:
The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous fibrosis (OSF), oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF. While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF, the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness. The vacillating expression patterns of OM-SCMs confirm the role of keratins 5, 14, 19, CD44, β1-integrin, p63, sex-determining region Y box (SOX2), octamer-binding transcription factor 4 (Oct-4), c-MYC, B-cell-specific Moloney murine leukaemia virus integration site 1 (Bmi-1) and aldehyde dehydrogenase 1 (ALDH1) in OSF, OPMDs and OSCC. The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.
