Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects.
- Author:
Yan CHEN
1
;
Chen CHEN
1
;
Xiaojuan ZHANG
1
;
Chuanchuan HE
1
;
Pengxuan ZHAO
1
;
Minsi LI
1
;
Ting FAN
1
;
Ruicong YAN
1
;
Yao LU
1
;
Robert J LEE
2
;
Muhammad Waseem KHAN
1
;
Muhammad SARFRAZ
1
;
Xiang MA
1
;
Tan YANG
1
;
Guangya XIANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Anti-metastasis; Complex; Curcumin; Drug delivery; Nanoparticles; Non-small cell lung cancer; Platinum
- From: Acta Pharmaceutica Sinica B 2020;10(6):1106-1121
- CountryChina
- Language:English
- Abstract: Platinum-based chemotherapy is used for non-small cell lung cancer (NSCLC). However, it has side effects and minimum efficacy against lung cancer metastasis. In this study, platinum-curcumin complexes were loaded into pH and redox dual-responsive nanoparticles (denoted as Pt-CUR@PSPPN) to facilitate intracellular release and synergistic anti-cancer effects. Pt-CUR@PSPPN was prepared by a nano-precipitation method and had a diameter of ∼100 nm. The nanoparticles showed increased anti-cancer effects both and . In addition, Pt-CUR@PSPPN blocked PI3K/AKT signal transduction pathway and inhibited MMP2 and VEGFR2, resulting in enhanced anti-metastatic activity. Furthermore, reduced side effects were also observed. In conclusion, Pt-CUR@PSPPN provided a novel and attractive therapeutic strategy for NSCLC.
