Efficient drug and gene delivery to liver fibrosis: rationale, recent advances, and perspectives.
10.1016/j.apsb.2020.03.007
- Author:
Somayeh MAHDINLOO
1
;
Seyed Hossein KIAIE
1
;
Ala AMIRI
2
;
Salar HEMMATI
3
;
Hadi VALIZADEH
4
;
Parvin ZAKERI-MILANI
5
Author Information
1. Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz 5166616471, Iran.
2. Faculty of Basic Sciences, Islamic Azad University, Science and Research Branch, Tehran 1477893855, Iran.
3. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran.
4. Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran.
5. Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran.
- Publication Type:Journal Article
- Keywords:
Drug delivery;
Gene therapy;
Hepatic stellate cell;
Herbal anti-fibrotic;
Lipid nanoparticle;
Liver fibrosis;
Viral and non-viral vector
- From:
Acta Pharmaceutica Sinica B
2020;10(7):1279-1293
- CountryChina
- Language:English
-
Abstract:
Liver fibrosis results from chronic damages together with an accumulation of extracellular matrix, and no specific medical therapy is approved for that until now. Due to liver metabolic capacity for drugs, the fragility of drugs, and the presence of insurmountable physiological obstacles in the way of targeting, the development of efficient drug delivery systems for anti-fibrotics seems vital. We have explored articles with a different perspective on liver fibrosis over the two decades, then collected and summarized the information by providing corresponding and cases. We have discussed the mechanism of hepatic fibrogenesis with different ways of fibrosis induction in animals. Furthermore, the critical chemical and herbal anti-fibrotics, biological molecules such as micro-RNAs, siRNAs, and growth factors, which can affect cell division and differentiation, are mentioned. Likewise, drug and gene delivery and therapeutic systems on and models are summarized in the data tables. This review article enlightens recent advances in emerging drugs and nanocarriers and represents perspectives on targeting strategies employed in liver fibrosis treatment.
