Mechanism of Ferroptosis and Its Research Progress in Lung Cancer.
10.3779/j.issn.1009-3419.2020.104.16
- Author:
Jinming WU
1
;
Lifang MA
2
;
Jiayi WANG
2
;
Yongxia QIAO
1
Author Information
1. Public Health School, Shanghai Jiaotong University, Shanghai 200025, China.
2. Shanghai Institute of Thoracic Tumors, Shanghai Chest Hospital, Shanghai 200030, China.
- Publication Type:Journal Article
- Keywords:
Agonist;
Ferroptosis;
Lung cancer;
Molecular mechanism
- From:
Chinese Journal of Lung Cancer
2020;23(9):811-817
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a recently recognized form of regulated cell death caused by an iron-dependent accumulation of lipid reactive species. However, little research on ferroptosis and lung cancer, one of the most common tumors, has been carried out. This paper tries to review the research progress of ferroptotic suppression and explain it from the different ways of ferroptosis occurrence. Furthermore, as inducing ferroptosis to treat cancer gets more attention, we introduce four kinds of ferroptosis-inducing compounds and new prospects for lung cancer therapy to provide new ideas for lung cancer treatment.
