A multicenter survey of antibiotic use in very and extremely low birth weight infants in Hunan Province.
- Author:
Ming-Jie WANG
1
;
Shao-Jie YUE
;
Jin LIN
;
Xi-Rong GAO
;
Xiao-Ming PENG
;
Meng-Yu CHEN
;
Hua-Bao PENG
;
Bei CAO
;
Yun-Qing ZENG
;
Shu-Lian WANG
;
Bo WEN
;
Xi-Lin HUANG
;
Xiao-Ping LI
;
Ai-Zhen ZHANG
;
Ting CAO
;
Yi-Hua CHEN
;
Tie-Qiang CHEN
;
Chun-Hua YE
;
Tao BO
;
De-Lin JIANG
;
Xiu-Qun HUANG
;
Na-Fang REN
;
Long-Zhang TAO
;
Fang YAO
;
Chang-Jun TIAN
;
Hong-Ming LI
;
Ai-Min ZHANG
;
Fu-Rong HUANG
;
Wei-Guo ZHANG
;
Xiang-Hong CHEN
;
Yu-Chan LIU
;
Zheng-Lin LIU
;
Yan-Shan XU
;
Jing-Song MING
;
Li CHEN
;
Ning-Yi ZHU
;
Jun-Min HE
;
Sai-Jun YI
;
Tuan-Mei WANG
;
Zhao-Hui LI
;
Gui-Tian WANG
Author Information
- Publication Type:Journal Article
- MeSH: Anti-Bacterial Agents; Birth Weight; Humans; Infant; Infant, Extremely Low Birth Weight; Infant, Newborn; Intensive Care Units, Neonatal; Surveys and Questionnaires
- From: Chinese Journal of Contemporary Pediatrics 2020;22(6):561-566
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the current status of antibiotic use for very and extremely low birth weight (VLBW/ELBW) infants in neonatal intensive care units (NICUs) of Hunan Province.
METHODS:The use of antibiotics was investigated in multiple level 3 NICUs of Hunan Province for VLBW and ELBW infants born between January, 2017 and December, 2017.
RESULTS:The clinical data of 1 442 VLBW/ELBW infants were collected from 24 NICUs in 2017. The median antibiotic use duration was 17 days (range: 0-86 days), accounting for 53.0% of the total length of hospital stay. The highest duration of antibiotic use was up to 91.4% of the total length of hospital stay, with the lowest at 14.6%. In 16 out of 24 NICUs, the antibiotic use duration was accounted for more than 50.0% of the hospitalization days. There were 113 cases with positive bacterial culture grown in blood or cerebrospinal fluid, making the positive rate of overall bacterial culture as 7.84%. The positive rate of bacterial culture in different NICUs was significantly different from 0% to 14.9%. The common isolated bacterial pathogens Klebsiella pneumoniae was 29 cases (25.7%); Escherichia coli 12 cases (10.6%); Staphylococcus aureus 3 cases (2.7%). The most commonly used antibiotics were third-generation of cephalosporins, accounting for 41.00% of the total antibiotics, followed by penicillins, accounting for 32.10%, and followed by carbapenems, accounting for 13.15%. The proportion of antibiotic use time was negatively correlated with birth weight Z-score and the change in weight Z-score between birth and hospital discharge (r=-0.095, -0.151 respectively, P<0.01), positively correlated with death/withdrawal of care (r=0.196, P<0.01).
CONCLUSIONS:Antibiotics used for VLBW/ELBW infants in NICUs of Hunan Province are obviously prolonged in many NICUs. The proportion of routine use of third-generation of cephalosporins and carbapenems antibiotics is high among the NICUs.
