A clinical analysis of neurobehavioral development within one year after birth in preterm infants with bronchopulmonary dysplasia.
- Author:
Jian GU
1
;
Shao-Zhen LIANG
;
Bi-Jun SHI
;
Chang-Yu LIAN
;
Xin-Qi ZHONG
Author Information
1. Department of Neonatology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, China. zhongxq2001@126.com.
- Publication Type:Journal Article
- MeSH:
Bronchopulmonary Dysplasia;
Gestational Age;
Humans;
Infant;
Infant, Newborn;
Infant, Premature;
Neonatal Screening;
Retrospective Studies
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(6):583-588
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of bronchopulmonary dysplasia (BPD) on neurobehavioral development within one year after birth in preterm infants.
METHODS:A retrospective analysis was performed for the preterm infants with a gestational age of <34 weeks who were born from September 2017 to December 2019 and completed the follow-up assessments of neurobehavioral development at the corrected gestational ages of 40 weeks and 3, 6, and 12 months. According to their diagnosis, they were divided into a BPD group with 23 infants and a non-BPD group with 27 infants. The outcome of neurobehavioral development was compared between the two groups at different time points.
RESULTS:There was no significant difference in the neonatal behavioral neurological assessment score between the BPD and non-BPD groups at the corrected gestational age of 40 weeks (P>0.05). Based on the Gesell Developmental Scale, compared with the non-BPD group, the BPD group had significantly lower global developmental quotient (DQ) and DQs of fine motor, adaptive behavior, and personal-social behavior at the corrected gestational ages of 3, 6, and 12 months (P<0.05). For both groups, the DQ of language at the corrected gestational age of 6 months was significantly higher than that at the corrected gestational age of 12 months (P<0.017), the DQ of personal-social behavior at the corrected gestational age of 6 months was significantly higher than that at the corrected gestational age of 3 months (P<0.017), and the DQ of adaptive behavior at the corrected gestational age of 12 months was significantly higher than that at the corrected gestational ages of 3 and 6 months (P<0.017). Based on the BSID-II scale, there were no significant differences in mental development index and psychomotor development index at each time point between the two groups (P>0.05). The mental development index at the corrected gestational age of 3 months was significantly higher than that at the corrected gestational ages of 6 and 12 months in both groups (P<0.001).
CONCLUSIONS:Preterm infants with BPD have delayed neurodevelopment within one year after birth compared with those without BPD, which should be taken seriously in clinical practice.
