Characteristics of pulmonary function in infants and young children with pertussis-like coughing.
- Author:
Jia-Ying CAO
1
;
Lu XU
;
Jia-Hua PAN
Author Information
1. Department of Pediatrics, Anhui Provincial Hospital, Hefei 230001, China. panjiahua1960@qq.com.
- Publication Type:Journal Article
- MeSH:
Child;
Child, Preschool;
Humans;
Infant;
Lung;
Respiration;
Respiratory Function Tests;
Tidal Volume;
Whooping Cough
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(8):839-843
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the characteristics of pulmonary function in children with pertussis-like coughing caused by different pathogen infections.
METHODS:The data on etiology and tidal breathing pulmonary function were collected from 95 hospitalized infants and young children with pertussis-like coughing. The tidal breathing pulmonary function was compared between these children and 67 healthy children. According to the type of pathogen, the children with pertussis-like coughing were classified to 6 groups: pertussis (n=17), viral infection (n=23), tuberculosis infection (n=6), Mycoplasma infection (n=9), other bacterial infection (n=8), and unknown pathogen (n=32).
RESULTS:Among the 95 children with pertussis-like coughing, 15 (16%) had mild obstructive ventilatory dysfunction, 30 (32%) had moderate obstructive ventilatory dysfunction, and 22 (23%) had severe obstructive ventilatory dysfunction. Compared with the normal control group, the children with pertussis-like coughing had significant reductions in inspiratory-to-expiratory time ratio, ratio of time to peak tidal expiratory flow to total expiratory time (tPF%tE), and ratio of volume to peak tidal expiratory flow to total expiratory volume (vPF%vE) (P<0.05). The tuberculosis infection and Mycoplasma infection groups had a significantly lower tidal volume than the normal control group (P<0.05). All pathogen infection groups except the tuberculosis infection group had significantly lower tPF%tE and vPF%vE than the normal control group (P<0.05). The pertussis group had significantly lower tPF%tE and vPF%vE than the other infection groups (P<0.05).
CONCLUSIONS:Most of children with pertussis-like coughing have abnormal pulmonary functions. The children with Bordetella pertussis infection have the most severe pulmonary function impairment. Tidal breathing pulmonary function test may provide a reference for pathogen analysis of children with pertussis-like coughing.
