Dyspnea and ventilator dependence after birth in a full-term female infant.
- Author:
Zi-Qi WU
1
;
Jun XU
;
Ai-Min ZHANG
;
Xing HU
;
Fu-Rong HUANG
Author Information
1. Department of Neonatology, Hunan Provincial People's Hospital/ First Affiliated Hospital of Hunan Normal University, Changsha 410005, China. Lilly610@sina.com.
- Publication Type:Case Reports
- MeSH:
Dyspnea;
Female;
Humans;
Infant;
Lung;
Lung Diseases, Interstitial;
Mutation;
Pulmonary Surfactants
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(8):897-902
- CountryChina
- Language:Chinese
-
Abstract:
A female infant, aged 43 days, had shortness of breath, cyanosis, groan, and dyspnea since birth. Physical examination showed cyanosis of lips and three-concave sign, and multiple lung imaging examinations showed diffuse ground-glass opacities in both lungs. The girl was given anti-infective therapy and continuous mechanical ventilation but there were no significant improvements in symptoms. Gene testing confirmed a compound heterozygous mutation, c.1890C>A(p.Tyr630Ter)+c.3208G>A(p.Ala1070Thr), in the ABCA3 gene, with the former from her father and the latter from her mother. Pathological examination of the lungs indicated pulmonary interstitial disease. The girl was diagnosed with infantile diffuse pulmonary interstitial disease caused by mutations in the ABCA3 gene. When full-term neonates experience shortness of breath and dyspnea after birth, pulmonary imaging suggests diffuse ground-glass changes, and conventional treatment is not effective (ventilator-dependent), congenital pulmonary surfactant metabolism defects needs to be considered. Gene testing, which can provide a basis for early intervention, prognostic evaluation, and genetic counseling, should be performed as early as possible.
