A clinical epidemiological investigation of neonatal acute respiratory distress syndrome in southwest Hubei, China.
- Author:
Yong-Fang ZHANG
1
;
Xin-Qiao YU
;
Jian-Hua LIAO
;
Feng YANG
;
Cong-Rong TAN
;
Su-Ying WU
;
Shi-Qing DENG
;
Jun-Yuan FENG
;
Jia-Yan HUANG
;
Zuo-Fen YUAN
;
Kai-Dian LIU
;
Zhen-Ju HUANG
;
Li-Fang ZHANG
;
Zheng-Guo CHEN
;
Hong XIA
;
Lin-Lin LUO
;
Yan HU
;
Hua-Sheng WU
;
Hong-Ling XIE
;
Bao-Min FEI
;
Qing-Wei PANG
;
Song-Hua ZHANG
;
Bi-Xia CHENG
;
Lang JIANG
;
Chang-Tao SHEN
;
Qiong YI
;
Xiao-Guang ZHOU
Author Information
1. Department of Pediatrics, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei 445000, China. yangzhuren88@163.com.
- Publication Type:Journal Article
- MeSH:
China;
Female;
Humans;
Infant, Newborn;
Meconium Aspiration Syndrome;
Pregnancy;
Respiratory Distress Syndrome, Newborn;
Retrospective Studies
- From:
Chinese Journal of Contemporary Pediatrics
2020;22(9):942-947
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical features and outcome of neonatal acute respiratory distress syndrome (ARDS) in southwest Hubei, China.
METHODS:According to the Montreux definition of neonatal ARDS, a retrospective clinical epidemiological investigation was performed on the medical data of neonates with ARDS who were admitted to Department of Neonatology/Pediatrics in 17 level 2 or level 3 hospitals in southwest Hubei from January to December, 2017.
RESULTS:A total of 7 150 neonates were admitted to the 17 hospitals in southwest Hubei during 2017 and 66 (0.92%) were diagnosed with ARDS. Among the 66 neonates with ARDS, 23 (35%) had mild ARDS, 28 (42%) had moderate ARDS, and 15 (23%) had severe ARDS. The main primary diseases for neonatal ARDS were perinatal asphyxia in 23 neonates (35%), pneumonia in 18 neonates (27%), sepsis in 12 neonates (18%), and meconium aspiration syndrome in 10 neonates (15%). Among the 66 neonates with ARDS, 10 neonates (15%) were born to the mothers with an age of ≥35 years, 30 neonates (45%) suffered from intrauterine distress, 32 neonates (49%) had a 1-minute Apgar score of 0 to 7 points, 24 neonates (36%) had abnormal fetal heart monitoring results, and 21 neonates (32%) experienced meconium staining of amniotic fluid. Intraventricular hemorrhage was the most common comorbidity (12 neonates), followed by neonatal shock (9 neonates) and patent ductus arteriosus (8 neonates). All 66 neonates with ARDS were treated with mechanical ventilation in addition to the treatment for primary diseases. Among the 66 neonates with ARDS, 10 died, with a mortality rate of 15% (10/66), and 56 neonates were improved or cured, with a survival rate of 85% (56/66).
CONCLUSIONS:Neonatal ARDS in southwest Hubei is mostly mild or moderate. Perinatal asphyxia and infection may be the main causes of neonatal ARDS in this area. Intraventricular hemorrhage is the most common comorbidity. Neonates with ARDS tend to have a high survival rate after multimodality treatment.
