Chemotherapy with Five-Day Continuous Infusion of 5-Fluorouracil (5-FU) Plus Cisplatin for Advanced Gastric Cancer; Significance of 5-FU Concentration Monitoring.
- Author:
Yeon Hee PARK
1
;
Bong Seog KIM
;
Baek Yeol RYOO
;
Tae You KIM
;
Young Hyuck IM
;
Ho Sang SHIN
;
Yoon Koo KANG
Author Information
1. Department of Internal Medicine, Korea Cancer Center Hospital, Seoul.
- Publication Type:Original Article
- Keywords:
Stomach neoplasm;
Continuous infusion;
5-FU;
Pharmacokinetics
- MeSH:
Area Under Curve;
Cisplatin*;
Drug Therapy*;
Fluorouracil*;
Humans;
Pharmacokinetics;
Plasma;
Stomach Neoplasms*;
Treatment Outcome
- From:Journal of the Korean Cancer Association
2000;32(3):516-523
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the therapeutic effects and toxicities of 5-day continuous infusion of 5-FU plus cisplatin FP chemotherapy in advanced gastric adendegrees Carcinoma and to elucidate the relationship between the pharmacokinetic (PK) parameters and therapeutic outcome. MATERIALS AND METHODS: Patients with previously untreated advanced stomach cancer were treated with FP chemotherapy. Plasma concentrations of 5-FU were measured using gas chro matography method for 5 days. Correlation of PK parameters of 5-FU with clinical outcome after FP chemotherapy was studied. RESULTS: Response rate of FP chemotherapy was 46% (95% C.I.: 30~62%). There was a wide range of difference in the concentration and area under the curve (AUC) of 5-FU from patient to patient. We could find significant differences in AUC of 5-FU between the responders and the non-responders (p<0.05). CONCLUSION: We could confirm that FP chemotherapy was effective and tolerable for the treatment of advanced stomach cancer. The monitoring of plasma 5-FU concentration after chemotherapy and the adjustment of subsequent 5-FU dose seems to be necessary to improve the treatment outcome of FP chemotherapy.
