Replication and transmission mechanisms of highly pathogenic human coronaviruses.
10.3785/j.issn.1008-9292.2020.06.01
- Author:
Yeyan HE
1
;
Chanying ZHENG
2
Author Information
1. College of Animal Science and Technology·College of Veterinary Medicine, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.
2. Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou 310029, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Betacoronavirus;
physiology;
Coronavirus Infections;
immunology;
transmission;
virology;
Humans;
Middle East Respiratory Syndrome Coronavirus;
physiology;
Pandemics;
Pneumonia, Viral;
immunology;
transmission;
virology;
SARS Virus;
physiology;
Virus Replication;
physiology
- From:
Journal of Zhejiang University. Medical sciences
2020;49(1):324-339
- CountryChina
- Language:Chinese
-
Abstract:
The three known human highly pathogenic coronaviruses are severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus, (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human highly pathogenic coronaviruses are composed of non-structural proteins, structural proteins and accessory proteins. Viral particles recognize host receptors via spike glycoprotein (S protein), enter host cells by membrane fusion, replicate in host cells through large replication-transcription complexes, and promote proliferation by interfering with and suppressing the host's immune response. Human highly pathogenic coronaviruses are hosted by humans and vertebrates. Viral particles are transmitted through droplets, contact and aerosols or likely through digestive tract, urine, eyes and other routes. This review discusses the mechanisms of proliferation and transmission of highly pathogenic human coronaviruses based on the results of existing research, providing basis for future study on interrupting the transmission and pathogenicity of human highly pathogenic coronaviruses.
