Follow-up testing of viral nucleic acid in discharged patients with moderate type of COVID-19.
10.3785/j.issn.1008-9292.2020.03.11
- Author:
Youjiang LI
1
;
Yingying HU
2
;
Xiaodong ZHANG
1
;
Yuanyuan YU
2
;
Bin LI
3
;
Jianguo WU
1
;
Yingping WU
1
;
Xiaoping XIA
1
;
Jian XU
2
Author Information
1. Clinical Laboratory, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, Zhejiang Province, China.
2. Department of Gynecology and Obstetrics, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, Zhejiang Province, China.
3. Department of Infection Diseases, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Betacoronavirus;
isolation & purification;
Coronavirus Infections;
diagnosis;
Feces;
chemistry;
virology;
Follow-Up Studies;
Humans;
Pandemics;
Patient Discharge;
statistics & numerical data;
Pneumonia, Viral;
diagnosis;
Quarantine;
statistics & numerical data;
RNA, Viral;
analysis;
Reverse Transcriptase Polymerase Chain Reaction;
Time Factors
- From:
Journal of Zhejiang University. Medical sciences
2020;49(2):270-274
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical outcome of patients with moderate type of coronavirus disease 2019 (COVID-19) after discharge by retesting viral nucleic acid.
METHODS:Seven patients with moderate COVID-19 met the discharge criteria enacted by National Health Commission were quarantined in hospital for 7 days, then continuously quarantined at home for 4 weeks after discharged. During the quarantined period, the symptoms and signs were documented, and sputum or nasal swab and feces samples were collected to test SARS-CoV-2 nucleic acid by RT-PCR method.
RESULTS:There was no symptoms and signs during the quarantine period in all 7 patients. However, respiratory swabs from 3 patients were confirmed positive of SARS-CoV-2 nucleic acid at 5 to 7 days after they met the discharge criteria.
CONCLUSIONS:There is a relatively high incidence of positive viral nucleic acid in patients met the discharge criteria, and it is suggested that patients met the current discharge criteria should be quarantined in hospital for another 7 days and the follow-up viral testing is necessary.
