Research progress on intrinsic signaling pathways in axon regeneration.
- Author:
Yifeng WANG
1
;
Zhiping WANG
1
Author Information
1. NHC and CAMS Key Laboratory of Medical Neurobiology, Center for Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Axons;
physiology;
Nerve Regeneration;
Neurons;
Phosphatidylinositol 3-Kinases;
Regeneration;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2020;49(1):82-89
- CountryChina
- Language:Chinese
-
Abstract:
The intrinsic regrowth ability of injured neurons is essential for axon regeneration and functional recovery. Recently, numerous intrinsic pathways that regulate axon regeneration have been discovered, among which the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway are arguably the best characterized examples. MAPK signaling pathway is involved in multiple processes including sensing injury signals, initiating and promoting axonal regrowth through regulating cytoskeleton dynamics and protein synthesis. The PI3K/Akt signaling pathway regulates axon regeneration mainly through gene transcription and translation. Combinatory manipulation of multiple regeneration-promoting signals can further improve the extend of axonal regrowth. This paper summarizes current progresses on axon regeneration studies in various organisms and discuss their potentials in promoting functional recovery .
