Therapeutic effect of laparoscopic Roux-en-Y gastric bypass in non-obese patients with type 2 diabetes.
- Author:
Zhuangwei WU
1
;
Liangping WU
2
;
Xiaojiang DAI
2
;
Weiguo ZHAO
2
;
Xiang YU
1
;
Zhigao SONG
3
;
Baolin YANG
2
;
Zonghai HUANG
1
Author Information
1. Special Medical Service Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
2. Department of Thyroid and Diabetes Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510168, China.
3. Center for Translational Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
- Publication Type:Journal Article
- MeSH:
Body Mass Index;
Diabetes Mellitus, Type 2;
surgery;
Gastric Bypass;
statistics & numerical data;
Humans;
Laparoscopy;
Retrospective Studies;
Treatment Outcome;
Weight Loss
- From:
Journal of Zhejiang University. Medical sciences
2020;40(7):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the effectiveness of laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery for treatment of type 2 diabetes (TD) in patients with a body mass index (BMI) < 27.5 kg/m.
METHODS:We retrospectively analyzed the data of patients who underwent LRYGB surgery from March, 2012 to June, 2018 in the General Hospital of Guangzhou Military Command and Jinshazhou Hospital of Guangzhou University of Chinese Medicine. The changes in the parameters of glucose metabolism and physical indicators of the patients in the first, second and third years after the surgery were analyzed in patients in low BMI group and high BMI group.
RESULTS:All the 74 patients underwent LRYGB successfully without conversion to open surgery. One year after the surgery, fasting blood glucose (FBG), HbA1c, postprandial blood glucose, fasting insulin, HOMA-IR, fasting C-peptide, BMI, body weight and waistline were significantly improved compared with their preoperative values in low BMI group ( < 0.05). At 2 years after the operation, FBG, HbA1c, postprandial blood glucose, HOMA-IR, BMI, body weight and waistline were significantly improved compared with the preoperative values in low BMI group ( < 0.05). In the third year, FBG, HOMA-IR, fasting C-peptide, body weight and waistline were significantly improved compared with the preoperative values in low BMI group ( < 0.05). There was no significant difference in the parameters of glucose metabolism and islet function between low BMI group and high BMI group at different stages. No serious complications occurred in these patients after the surgery.
CONCLUSIONS:LRYGB is effective for treatment of T2D in Chinese patients with a BMI < 27.5. After the surgery, the patient show reduced waistline without significant weight loss. The long-term results of the surgery still require further investigations with a larger samples and longer follow-up.
